(in grassetto le squadre qualificate ai quarti)
- Slavia Praga-Milan 1-3 (33′ Pulisic, 36′ Loftus-Cheek, 45’+6 Leao, 84′ Jurasek)
- Rangers-Benfica 0-1 (66′ Rafa Silva)
- Villarreal-Marsiglia 3-1 (32′ Capoue, 54′ Sorloth, 85′ Mosquera, 94′ Clauss)
- West Ham-Friburgo 5-0 (9′ Paquetà, 32′ Bowen, 52′ Cresswell, 77′ Kudus, 85′ Kudus)
- Atalanta-Sporting 2-1 (33′ Goncalves, 46′ Lookman, 59′ Scamacca)
- Brighton-Roma 1-0 (37′ Welbeck)
- Bayer Leverkusen-Qarabag 3-2 (58′ Zoubir, 67′ Juninho, 72′ Frimpong, 93′ e 97′ Schick)
- Liverpool-Sparta Praga 6-1 (7′ Nunez, 8′ Clark, 10′ Salah, 14′ e 55′ Gakpo, 42′ Birmancevic, 48′ Szoboszlai)
